Vagus nerve stimulation: A new approach to reduce heart failure
De Ferrari GM, Klein H.U.
Article. Published in Cardiology Journal 2010, Vol. 17, No. 6, pp: 638–643.Experimental data have demonstrated that stimulation of the vagus nerve is able to reverse ventricular remodeling of the failing heart. There is also evidence that increasing parasympathetic activity may stimulate the production of nitric oxide, and reduce the devastating inflammatory process involved in HF. Vagus nerve stimulation (VNS) has been successfully applied for many years to treat drug resistant epilepsy.